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Article

Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers.

Nature communications - 2 Feb 2016

Llanos Susana, García-Pedrero Juana M, Morgado-Palacin Lucia, Rodrigo Juan P, Serrano Manuel

Abstract excerpt

The levels, regulation and prognostic value of p21 in head and neck squamous cell carcinomas (HNSCC) has been puzzling for years. Here, we report a new mechanism of regulation of p21 by the mTORC1/4E-BP1 pathway. We find that non-phosphorylated 4E-BP1 interacts with p21 and induces its degradation. Accordingly, hyper-activation of mTORC1 results in phosphorylation of 4E-BP1 and stabilization of p21. In HNSCC, p21...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p21

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Share to Mechanistic Target of Rapamycin Complex 1

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Identifiers

PMID: 26832959
DOI: 10.1038/ncomms10438
PMCID: PMC4740818

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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