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Article

SOCS3 is epigenetically up-regulated in steroid resistant nephrotic children.

Acta biochimica Polonica - 1 Jan 2016

Zaorska Katarzyna, Zawierucha Piotr, Ostalska-Nowicka Danuta, Nowicki Michał

Abstract excerpt

BACKGROUND: The mechanism of steroid resistance in children with the nephrotic syndrome is yet unknown. About 20% of patients demonstrate steroid unresponsiveness and progress to end stage renal disease. Aberrant SOCS3 and SOCS5 expression in steroid resistant and sensitive patients has previously been demonstrated. Here, we investigate genetic and epigenetic mechanisms of regulation of SOCS3 and SOCS5...

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Share to Case-Control Studies
Share to DNA Methylation
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nephrotic Syndrome

Share to Promoter Regions, Genetic

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Share to Suppressor of Cytokine Signaling 3 Protein

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Source

Identifiers

PMID: 26828667
DOI: 10.18388/abp.2015_1105

Genes

SOCS3
SOCS5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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