MDR-1 and CYP3A5 Polymorphisms in Pediatric Idiopathic Nephrotic Syndrome: Impact on Susceptibility and Response to Steroids (Preliminary Results).

doi:10.7754/Clin.Lab.2017.170203

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Article

MDR-1 and CYP3A5 Polymorphisms in Pediatric Idiopathic Nephrotic Syndrome: Impact on Susceptibility and Response to Steroids (Preliminary Results).

Clinical laboratory - 1 Jul 2017

Moussa Amira, Mabrouk Sameh, Hamdouni Haithem, Ajmi Maroua, Tfifha Miniar, Omezzine Asma, Abroug Saoussen, Bouslama Ali

Abstract excerpt

BACKGROUND: Oral steroid treatment is the first line of therapy for childhood nephrotic syndrome (NS). However, resistance to this treatment has been observed in some patients. Here, we investigated the association of two steroid metabolism-related genes with susceptibility to childhood NS and the steroid response. METHODS: We genotyped the single nucleotide polymorphisms (SNP) of MDR-1 [C1236T (rs1128503),...

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PMID: 28792718
DOI: 10.7754/Clin.Lab.2017.170203

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