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Article

NR3C1 variants and glucocorticoid response in childhood nephrotic syndrome in North India.

BMC nephrology - 14 May 2025

Paranthaman Sarranya, Srivastava Priyanka, Kumari Anu, Bhardwaj Chitra, Bawa Pratibha, Kaur Anupriya, Panigrahi Inusha, Dawman Lesa, Tiewsoh Karalanglin

Abstract excerpt

BACKGROUND: Nephrotic syndrome (NS) is a common kidney disorder in children, characterized by significant proteinuria, hypoalbuminemia, and peripheral edema. While glucocorticoids (GCs) are the first-line treatment for pediatric nephrotic syndrome (NS), a subset of patients exhibit steroid resistance, leading to poor prognosis and a higher risk of long-term kidney damage. The glucocorticoid receptor gene (NR3C1)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40369478
DOI: 10.1186/s12882-025-04173-5
PMCID: PMC12080024

Genes

NR3C1
GC

Provenance

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