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Article

Multiple gene sequencing for risk assessment in patients with early-onset or familial breast cancer.

Oncotarget - 16 Feb 2016

Lin Po-Han, Kuo Wen-Hung, Huang Ai-Chu, Lu Yen-Shen, Lin Ching-Hung, Kuo Sung-Hsin, Wang Ming-Yang, Liu Chun-Yu, Cheng Fiona Tsui-Fen, Yeh Ming-Hsin, Li Huei-Ying, Yang Yu-Hsuan, Hsu Yu-Hua, Fan Sheng-Chih, Li Long-Yuan, Yu Sung-Liang, Chang King-Jen, Chen Pei-Lung, Ni Yen-Hsuan, Huang Chiun-Sheng

Abstract excerpt

Since BRCA mutations are only responsible for 10-20% of cases of breast cancer in patients with early-onset or a family history and since next-generation sequencing technology allows the simultaneous sequencing of a large number of target genes, testing for multiple cancer-predisposing genes is now being considered, but its significance in clinical practice remains unclear. We then developed a sequencing panel...

Read the complete abstract on PubMed

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Source

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Identifiers

PMID: 26824983
DOI: 10.18632/oncotarget.7027
PMCID: PMC4884994

Genes

RAD50
ATM
BRCA1
BRCA2
BRIP1
FANCI
MSH2
MUTYH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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