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Clinical Contribution of Next-Generation Sequencing Multigene Panel Testing for BRCA Negative High-Risk Patients With Breast Cancer.

Clinical breast cancer - 1 Dec 2021

Ece Solmaz Aslı, Yeniay Levent, Gökmen Erhan, Zekioğlu Osman, Haydaroğlu Ayfer, Bilgen Işıl, Özkınay Ferda, Onay Hüseyin

Abstract excerpt

BACKGROUND: Breast cancer is the most common malignancy in women and thought to be hereditary in 10% of patients. Recent next-generation sequencing studies have increased the detection of pathogenic or likely pathogenic (P/LP) variants in genes other than BRCA1/2 in patients with breast cancer. This study evaluated pathogenic variants, likely pathogenic variants, and variants of unknown significance in 18...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33980423
DOI: 10.1016/j.clbc.2021.04.002

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