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Article

Comparison of Patient Susceptibility Genes Across Breast Cancer: Implications for Prognosis and Therapeutic Outcomes

1 Jul 2020

Abstract excerpt

Abstract: Hereditary breast cancer syndromes affect a small (10– 15% of cases) but significant group of patients. BRCA1 and BRCA2 are the most familiar and well-studied genes associated with inherited breast cancer. However, mutations in the high-penetrance genes, TP53, PTEN, CDH1, MSH1, MLH1, MSH6, PMS2, PALB2 , and STK11 , and in the moderate-penetrance genes, CHEK2, ATM, and BRIP1 , also correlate with high...

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PMID: 32801835
DOI: 10.2147/pgpm.s233485

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