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Article

PCA-based GRS analysis enhances the effectiveness for genetic correlation detection.

Briefings in bioinformatics - 27 Nov 2019

Zhao Yan, Ning Yujie, Zhang Feng, Ding Miao, Wen Yan, Shi Liang, Wang Kunpeng, Lu Mengnan, Sun Jingyan, Wu Menglu, Cheng Bolun, Ma Mei, Zhang Lu, Cheng Shiqiang, Shen Hui, Tian Qing, Guo Xiong, Deng Hong-Wen

Abstract excerpt

Genetic risk score (GRS, also known as polygenic risk score) analysis is an increasingly popular method for exploring genetic architectures and relationships of complex diseases. However, complex diseases are usually measured by multiple correlated phenotypes. Analyzing each disease phenotype individually is likely to reduce statistical power due to multiple testing correction. In order to conquer the...

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PMID: 30169568
DOI: 10.1093/bib/bby075
PMCID: PMC6954421

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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