Article
A null mutation in ANGPTL8 does not associate with either plasma glucose or type 2 diabetes in humans.
BMC endocrine disorders - 28 Jan 2016
Clapham Katharine R, Chu Audrey Y, Wessel Jennifer, Natarajan Pradeep, Flannick Jason, Rivas Manuel A, Sartori Samantha, Mehran Roxana, Baber Usman, Fuster Valentin, Scott Robert A, Rader Daniel J, Boehnke Michael, McCarthy Mark I, Altshuler David M, Kathiresan Sekar, Peloso Gina M
Abstract excerpt
BACKGROUND: Experiments in mice initially suggested a role for the protein angiopoietin-like 8 (ANGPTL8) in glucose homeostasis. However, subsequent experiments in model systems have challenged this proposed role. We sought to better understand the importance of ANGPTL8 in human glucose homeostasis by examining the association of a null mutation in ANGPTL8 with fasting glucose levels and risk for type 2 diabetes....
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