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Article

Haplotype structure of the ENPP1 Gene and Nominal Association of the K121Q missense single nucleotide polymorphism with glycemic traits in the Framingham Heart Study.

Diabetes - 1 Jul 2008

Stolerman Elliot S, Manning Alisa K, McAteer Jarred B, Dupuis Josée, Fox Caroline S, Cupples L Adrienne, Meigs James B, Florez Jose C

Abstract excerpt

OBJECTIVE: A recent meta-analysis demonstrated a nominal association of the ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) K-->Q missense single nucleotide polymorphism (SNP) at position 121 with type 2 diabetes. We set out to confirm the association of ENPP1 K121Q with hyperglycemia, expand this association to insulin resistance traits, and determine whether the association stems from K121Q or...

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Source

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Identifiers

PMID: 18426862
DOI: 10.2337/db08-0266
PMCID: PMC2453609

Genes

ENPP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Haplotype structure of the ENPP1 Gene and Nominal Association of the K121Q missense single nucleotide polymorphism with glycemic traits in the Framingham Heart Study.PMID 18426862Read ↗

The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects.Semantic proximity Read ↗

New polymorphism of ENPP1 (PC-1) is associated with increased risk of type 2 diabetes among obese individuals.Semantic proximity Read ↗

The association of ENPP1 K121Q with diabetes incidence is abolished by lifestyle modification in the diabetes prevention program.Semantic proximity Read ↗

Common variants in the ENPP1 gene are not reproducibly associated with diabetes or obesity.Semantic proximity Read ↗

No evidence of association of ENPP1 variants with type 2 diabetes or obesity in a study of 8,089 U.K. Caucasians.Semantic proximity Read ↗

Association of the ENPP1 K121Q polymorphism with susceptibility to type 2 diabetes in different populations: evidence based on 40 studies.Semantic proximity Read ↗

ENPP1 gene, insulin resistance and related clinical outcomes.Semantic proximity Read ↗

Association of the Q121 variant of ENPP1 gene with decreased kidney function among patients with type 2 diabetes.Semantic proximity Read ↗

Association of K121Q polymorphism in ENPP1 (PC-1) with BMI in Caucasian and African-American adults.Semantic proximity Read ↗

ENPP1/PC-1 gene K121Q polymorphism is associated with obesity in European adult populations: evidence from a meta-analysis involving 24,324 subjects.Semantic proximity Read ↗

ENPP1 K121Q polymorphism and obesity, hyperglycaemia and type 2 diabetes in the prospective DESIR Study.Semantic proximity Read ↗

The ENPP1 K121Q polymorphism is associated with type 2 diabetes and related metabolic phenotypes in a Taiwanese population.Semantic proximity Read ↗

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