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Article

Frequent variations in cancer-related genes may play prognostic role in treatment of patients with chronic myeloid leukemia.

BMC genetics - 27 Jan 2016

Lavrov Alexander V, Chelysheva Ekaterina Y, Smirnikhina Svetlana A, Shukhov Oleg A, Turkina Anna G, Adilgereeva Elmira P, Kutsev Sergey I

Abstract excerpt

BACKGROUND: Genome variability of host genome and cancer cells play critical role in diversity of response to existing therapies and overall success in treating oncological diseases. In chronic myeloid leukemia targeted therapy with tyrosine kinase inhibitors demonstrates high efficacy in most of the patients. However about 15 % of patients demonstrate primary resistance to standard therapy. Whole exome...

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Source

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Identifiers

PMID: 26822197
DOI: 10.1186/s12863-015-0308-7
PMCID: PMC4895599

Genes

DNAH9
MAGEC1
PTCRA
THSD1
TOX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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