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Integrated Genomic Analysis Identifies ANKRD36 Gene as a Novel and Common Biomarker of Disease Progression in Chronic Myeloid Leukemia

2024-01-03

Abstract excerpt

<h4>Background: </h4> Chronic Myeloid Leukemia (CML) is initiated in bone marrow due to chromosomal translocation t(22;9) leading to fusion oncogene BCR-ABL. Targeting BCR-ABL by tyrosine kinase inhibitors (TKI) have changed fatal CML into an almost curable disease. Despite that, TKIs lose their effectiveness due to disease progression. Unfortunately, mechanism of CML progression is poorly understood and common bi...

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Literature Corpus work
058a7238-7a05-5063-a54c-6ff9566dc8d8
DOI
10.20944/preprints202108.0498.v2
Open publication

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