Article
Discovery of sexual dimorphisms in metabolic and genetic biomarkers.
PLoS genetics - 1 Aug 2011
Mittelstrass Kirstin, Ried Janina S, Yu Zhonghao, Krumsiek Jan, Gieger Christian, Prehn Cornelia, Roemisch-Margl Werner, Polonikov Alexey, Peters Annette, Theis Fabian J, Meitinger Thomas, Kronenberg Florian, Weidinger Stephan, Wichmann Heinz Erich, Suhre Karsten, Wang-Sattler Rui, Adamski Jerzy, Illig Thomas
Abstract excerpt
Metabolomic profiling and the integration of whole-genome genetic association data has proven to be a powerful tool to comprehensively explore gene regulatory networks and to investigate the effects of genetic variation at the molecular level. Serum metabolite concentrations allow a direct readout of biological processes, and association of specific metabolomic signatures with complex diseases such as Alzheimer's...
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