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Article

Very-low and low-density lipoproteins induce neutral lipid accumulation and impair migration in monocyte subsets.

Scientific reports - 29 Jan 2016

Jackson William D, Weinrich Tobias W, Woollard Kevin J

Abstract excerpt

Blood monocytes are heterogeneous effector cells of the innate immune system. In circulation these cells are constantly in contact with lipid-rich lipoproteins, yet this interaction is poorly characterised. Our aim was to examine the functional effect of hyperlipidaemia on blood monocytes. In the Ldlr(-/-) mouse monocytes rapidly accumulate cytoplasmic neutral lipid vesicles during hyperlipidaemia. Functional...

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Identifiers

PMID: 26821597
DOI: 10.1038/srep20038
PMCID: PMC4731823

Genes

RHOA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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