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Article

Remnant Cholesterol Elicits Arterial Wall Inflammation and a Multilevel Cellular Immune Response in Humans.

Arteriosclerosis, thrombosis, and vascular biology - 1 May 2017

Bernelot Moens Sophie J, Verweij Simone L, Schnitzler Johan G, Stiekema Lotte C A, Bos Merijn, Langsted Anne, Kuijk Carlijn, Bekkering Siroon, Voermans Carlijn, Verberne Hein J, Nordestgaard Børge G, Stroes Erik S G, Kroon Jeffrey

Abstract excerpt

OBJECTIVE: Mendelian randomization studies revealed a causal role for remnant cholesterol in cardiovascular disease. Remnant particles accumulate in the arterial wall, potentially propagating local and systemic inflammation. We evaluated the impact of remnant cholesterol on arterial wall inflammation, circulating monocytes, and bone marrow in patients with familial dysbetalipoproteinemia (FD). APPROACH AND...

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PMID: 28336558
DOI: 10.1161/ATVBAHA.116.308834

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