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Deep Phenotyping by Mass Cytometry and Single-Cell RNA-Sequencing Reveals LYN-Regulated Signaling Profiles Underlying Monocyte Subset Heterogeneity and Lifespan.

Circulation research - 8 May 2020

Roberts Morgan E, Barvalia Maunish, Silva Jessica A F D, Cederberg Rachel A, Chu William, Wong Amanda, Tai Daven C, Chen Sam, Matos Israel, Priatel John J, Cullis Pieter R, Harder Kenneth W

Abstract excerpt

RATIONALE: Monocytes are key effectors of the mononuclear phagocyte system, playing critical roles in regulating tissue homeostasis and coordinating inflammatory reactions, including those involved in chronic inflammatory diseases such as atherosclerosis. Monocytes have traditionally been divided into 2 major subsets termed conventional monocytes and patrolling monocytes (pMo) but recent systems immunology...

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PMID: 32151196
DOI: 10.1161/CIRCRESAHA.119.315708

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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