Article
A Bioinformatics Approach to the Identification of Variants Associated with Type 1 and Type 2 Diabetes Mellitus that Reside in Functionally Validated miRNAs Binding Sites.
Biochemical genetics - 1 Jun 2016
Ghaedi Hamid, Bastami Milad, Jahani Mohammad Mehdi, Alipoor Behnam, Tabasinezhad Maryam, Ghaderi Omar, Nariman-Saleh-Fam Ziba, Mirfakhraie Reza, Movafagh Abolfazl, Omrani Mir Davood, Masotti Andrea
Abstract excerpt
The present work is aimed at finding variants associated with Type 1 and Type 2 diabetes mellitus (DM) that reside in functionally validated miRNAs binding sites and that can have a functional role in determining diabetes and related pathologies. Using bioinformatics analyses we obtained a database of validated polymorphic miRNA binding sites which has been intersected with genes related to DM or to variants...
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