Article
dbSMR: a novel resource of genome-wide SNPs affecting microRNA mediated regulation.
BMC bioinformatics - 16 Apr 2009
Hariharan Manoj, Scaria Vinod, Brahmachari Samir K
Abstract excerpt
BACKGROUND: MicroRNAs (miRNAs) regulate several biological processes through post-transcriptional gene silencing. The efficiency of binding of miRNAs to target transcripts depends on the sequence as well as intramolecular structure of the transcript. Single Nucleotide Polymorphisms (SNPs) can contribute to alterations in the structure of regions flanking them, thereby influencing the accessibility for miRNA...
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