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Article

Single-nucleotide polymorphisms inside microRNA target sites influence the susceptibility to type 2 diabetes.

Journal of human genetics - 1 Mar 2013

Zhao Xu, Ye Qing, Xu Kang, Cheng Jinluo, Gao Yanqin, Li Qian, Du Juan, Shi Hui, Zhou Ling

Abstract excerpt

MicroRNAs (miRNAs) negatively regulate target gene expression by binding to 3'-untranslated region of target mRNA. Single-nucleotide polymorphisms (SNPs) that reside in the miRNA target sites can affect the bindings of miRNAs to mRNAs. Compelling evidence has shown that miRNAs contribute to the etiology of type 2 diabetes (T2DM). We hypothesized that SNPs in diabetes-related miRNA target-binding sites could be...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23303383
DOI: 10.1038/jhg.2012.146

Genes

ACSL1
FABP2
INSR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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