Article
Characterizing redescriptions using persistent homology to isolate genetic pathways contributing to pathogenesis.
BMC systems biology - 11 Jan 2016
Platt Daniel E, Basu Saugata, Zalloua Pierre A, Parida Laxmi
Abstract excerpt
BACKGROUND: Complex diseases may have multiple pathways leading to disease. E.g. coronary artery disease evolves from arterial damage to their epithelial layers, but has multiple causal pathways. More challenging, those pathways are highly correlated within metabolic syndrome. The challenge is to identify specific clusters of phenotype characteristics (composite phenotypes) that may reflect these different...
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