Fully Bayesian analysis of allele-specific RNA-seq data.

Abstract excerpt

Diploid organisms have two copies of each gene, called alleles, that can be separately transcribed. The RNA abundance associated to any particular allele is known as allele-specific expression (ASE). When two alleles have polymorphisms in transcribed regions, ASE can be studied using RNA-seq read count data. ASE has characteristics different from the regular RNA-seq expression: ASE cannot be assessed for every...

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