ASAS-EGB: A statistical framework for estimating allele-specific alternative splicing events using transcriptome data.

Abstract excerpt

Ubiquitous Alternative splicing (AS) in eukaryotes greatly increases the biodiversity of proteins and involves in disease and cancer. Allele-specific AS studies can facilitate the identification of cis-acting elements because both alleles share the same cellular environment. Due to the limited information provided on the exons defined by AS events, we propose a statistical framework and algorithm ASAS-EGB for...

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