Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prospective pilot trial of PerMIT versus standard anticoagulation service management of patients initiating oral anticoagulation.

Thrombosis and haemostasis - 1 Sept 2012

Borgman Mark P, Pendleton Robert C, McMillin Gwendolyn A, Reynolds Kristen K, Vazquez Sara, Freeman Andrew, Wilson Andrew, Valdes Roland, Linder Mark W

Abstract excerpt

We performed a randomised pilot trial of PerMIT, a novel decision support tool for genotype-based warfarin initiation and maintenance dosing, to assess its efficacy for improving warfarin management. We prospectively studied 26 subjects to compare PerMIT-guided management with routine anticoagulation service management. CYP2C9 and VKORC1 genotype results for 13 subjects randomly assigned to the PerMIT arm...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Atrial Fibrillation
Share to Decision Support Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Management

Share to Drug Monitoring

Share to International Normalized Ratio

Share to Metabolic Clearance Rate

Share to Vitamin K Epoxide Reductases

Share to Warfarin

Source

Open in PubMed Open full text

Identifiers

PMID: 22836303
DOI: 10.1160/TH12-03-0159
PMCID: PMC3434319

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prospective pilot trial of PerMIT versus standard anticoagulation service management of patients initiating oral anticoagulation.PMID 22836303Read ↗

A randomized trial of genotype-guided dosing of warfarin.Semantic proximity Read ↗

Prospective evaluation of a pharmacogenetics-guided warfarin loading and maintenance dose regimen for initiation of therapy.Semantic proximity Read ↗

The Creating an Optimal Warfarin Nomogram (CROWN) Study.Semantic proximity Read ↗

A randomized controlled trial of genotype-based Coumadin initiation.Semantic proximity Read ↗

A prospective, randomized pilot trial of model-based warfarin dose initiation using CYP2C9 genotype and clinical data.Semantic proximity Read ↗

S-warfarin limited sampling strategy with a population pharmacokinetic approach to estimate exposure and cytochrome P450 (CYP) 2C9 activity in healthy adults.Semantic proximity Read ↗

Interactive modeling for ongoing utility of pharmacogenetic diagnostic testing: application for warfarin therapy.Semantic proximity Read ↗

Determinants of the over-anticoagulation response during warfarin initiation therapy in Asian patients based on population pharmacokinetic-pharmacodynamic analyses.Semantic proximity Read ↗

Clinical and genetic determinants of warfarin pharmacokinetics and pharmacodynamics during treatment initiation.Semantic proximity Read ↗

Feasibility of Implementing a Comprehensive Warfarin Pharmacogenetics ServiceSemantic proximity Read ↗

S-Warfarin Limited Sampling Models to Estimate Area Under the Concentration Versus Time Curve for Cytochrome P450 2C9 Baseline Activity and After Induction.Semantic proximity Read ↗

A PK-PD model for predicting the impact of age, CYP2C9, and VKORC1 genotype on individualization of warfarin therapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.