Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rapamycin ester analog CCI-779/Temsirolimus alleviates tau pathology and improves motor deficit in mutant tau transgenic mice.

Journal of Alzheimer's disease : JAD - 1 Jan 2015

Frederick Christelle, Ando Kunie, Leroy Karelle, Héraud Céline, Suain Valérie, Buée Luc, Brion Jean-Pierre

Abstract excerpt

Neurofibrillary tangles are intracellular inclusions made of tau protein that accumulates in neurons in Alzheimer's disease (AD) and in other tauopathies. We have investigated the ability of the rapamycin ester CCI-779/Temsilorimus, a mTOR inhibitor with better stability and pharmacological properties compared to rapamycin, to interfere with the development of a motor phenotype and tau pathology in a mutant tau...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Movement Disorders
Share to rab GTP-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to rab7 GTP-Binding Proteins

Share to Rotarod Performance Test

Share to Sirolimus

Share to tau Proteins

Share to Tauopathies

Share to TOR Serine-Threonine Kinases

Source

Identifiers

PMID: 25408212
DOI: 10.3233/JAD-142097

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rapamycin ester analog CCI-779/Temsirolimus alleviates tau pathology and improves motor deficit in mutant tau transgenic mice.PMID 25408212Read ↗

<scp>mTOR</scp> regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathiesSemantic proximity Read ↗

Rapamycin Attenuates the Progression of Tau Pathology in P301S Tau Transgenic MiceSemantic proximity Read ↗

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease.Semantic proximity Read ↗

An mTOR-independent Macroautophagy Activator Ameliorates Tauopathy and Prionopathy Neurodegeneration PhenotypesSemantic proximity Read ↗

Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons.Semantic proximity Read ↗

Targeting mTOR restores tau-induced metabolic, mitochondrial, and cognitive deficits in a tauopathy mouse modelSemantic proximity Read ↗

Targeting molecules to medicine with mTOR, autophagy and neurodegenerative disordersSemantic proximity Read ↗

Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegenerationSemantic proximity Read ↗

Rapamycin alleviates toxicity of different aggregate-prone proteins.Semantic proximity Read ↗

NVP-BEZ235 enhances autophagy and ameliorates cognitive deficits by targeting tauopathiesSemantic proximity Read ↗

Chronic Rapamycin administration via drinking water mitigates the pathological phenotype in a Krabbe disease mouse model through autophagy activation.Semantic proximity Read ↗

Autophagy activation ameliorates neuronal pathogenesis of FTLD-U miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.