Article
CRISPR/Cas9-mediated mutation of tyrosinase (Tyr) 3' UTR induce graying in rabbit.
Scientific reports - 8 May 2017
Song Yuning, Xu Yuxin, Deng Jichao, Chen Mao, Lu Yi, Wang Yong, Yao Haobin, Zhou Lina, Liu Zhiquan, Lai Liangxue, Li Zhanjun
Abstract excerpt
The 3' untranslated regions (UTRs), located at the end of mRNA molecules, are believed to play a role in RNA replication and/or protein translation. Mutations in the tyrosinase (Tyr) gene are known to cause recessive albinism in humans and other species. In this study, to test whether the CRISPR/Cas9 system works on the mutation of the UTRs regulatory region in rabbit, the 3' UTR of the rabbit Tyr gene was...
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