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Article

Makorin ortholog LEP-2 regulates LIN-28 stability to promote the juvenile-to-adult transition in Caenorhabditis elegans.

Development (Cambridge, England) - 1 Mar 2016

Herrera R Antonio, Kiontke Karin, Fitch David H A

Abstract excerpt

The heterochronic genes lin-28, let-7 and lin-41 regulate fundamental developmental transitions in animals, such as stemness versus differentiation and juvenile versus adult states. We identify a new heterochronic gene, lep-2, in Caenorhabditis elegans. Mutations in lep-2 cause a delay in the juvenile-to-adult transition, with adult males retaining pointed, juvenile tail tips, and displaying defective sexual...

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Identifiers

PMID: 26811380
DOI: 10.1242/dev.132738
PMCID: PMC4813343

Genes

LEP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Makorin ortholog LEP-2 regulates LIN-28 stability to promote the juvenile-to-adult transition in Caenorhabditis elegans.PMID 26811380Read ↗

The Makorin lep-2 and the lncRNA lep-5 regulate lin-28 to schedule sexual maturation of the C. elegans nervous systemSemantic proximity Read ↗

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LIN-42/PERIOD controls cyclical and developmental progression of C. elegans molts.Semantic proximity Read ↗

A branched heterochronic pathway directs juvenile-to-adult transition through two LIN-29 isoforms.Semantic proximity Read ↗

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Novel gain-of-function alleles demonstrate a role for the heterochronic gene lin-41 in C. elegans male tail tip morphogenesis.Semantic proximity Read ↗

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