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Reduced Gene Dosage of Tfap2c Impairs Trophoblast Lineage Differentiation and Alters Maternal Blood Spaces in the Mouse Placenta.

Biology of reproduction - 1 Aug 2015

Kaiser Stephanie, Koch Yvonne, Kühnel Elisabeth, Sharma Neha, Gellhaus Alexandra, Kuckenberg Peter, Schorle Hubert, Winterhager Elke

Abstract excerpt

Tfap2c is required for placental development and trophoblast stem cell maintenance. Deletion of Tfap2c results in early embryonic loss because of failure in placental development. We evaluated the effect of reduced Tfap2c expression on fetal outcome and placental development. Sixty percent of the heterozygous mice were lost directly after birth. Labyrinthine differentiation was impaired, as indicated by enhanced...

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PMID: 26063869
DOI: 10.1095/biolreprod.114.126474

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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