Article
Essential Role for Survivin in the Proliferative Expansion of Progenitor and Mature B Cells.
Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2016
Miletic Ana V, Jellusova Julia, Cato Matthew H, Lee Charlotte R, Baracho Gisele V, Conway Edward M, Rickert Robert C
Abstract excerpt
Survivin is a member of the inhibitor of apoptosis family of proteins and a biomarker of poor prognosis in aggressive B cell non-Hodgkin's lymphoma. In addition to its role in inhibition of apoptosis, survivin also regulates mitosis. In this article, we show that deletion of survivin during early B cell development results in a complete block at the cycling pre-B stage. In the periphery, B cell homeostasis is not...
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