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Article

Essential role of survivin, an inhibitor of apoptosis protein, in T cell development, maturation, and homeostasis.

The Journal of experimental medicine - 5 Jan 2004

Xing Zheng, Conway Edward M, Kang Chulho, Winoto Astar

Abstract excerpt

Survivin is an inhibitor of apoptosis protein that also functions during mitosis. It is expressed in all common tumors and tissues with proliferating cells, including thymus. To examine its role in apoptosis and proliferation, we generated two T cell-specific survivin-deficient mouse lines with deletion occurring at different developmental stages. Analysis of early deleting survivin mice showed arrest at the...

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Identifiers

PMID: 14699085
DOI: 10.1084/jem.20031588
PMCID: PMC1887718

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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