Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pleiotropic cell-division defects and apoptosis induced by interference with survivin function.

Nature cell biology - 1 Dec 1999

Li F, Ackermann E J, Bennett C F, Rothermel A L, Plescia J, Tognin S, Villa A, Marchisio P C, Altieri D C

Abstract excerpt

Here we investigate the role of the control of apoptosis in normal cell division. We show that interference with the expression or function of the apoptosis inhibitor survivin causes caspase-dependent cell death in the G2/M phase of the cell cycle, and a cell-division defect characterized by cent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caspase 3
Share to Caspases
Share to Centrosome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p21

Share to Inhibitor of Apoptosis Proteins

Share to Oligonucleotides, Antisense

Share to Spindle Apparatus

Share to Survivin

Source

Identifiers

PMID: 10587640
DOI: 10.1038/70242

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-10587640-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pleiotropic cell-division defects and apoptosis induced by interference with survivin function.PMID 10587640Read ↗

Molecular circuits of apoptosis regulation and cell division control: The survivin paradigmSemantic proximity Read ↗

Control of apoptosis and mitotic spindle checkpoint by survivin.Semantic proximity Read ↗

Cell division and cell survival in the absence of survivinSemantic proximity Read ↗

Cell Cycle and ApoptosisSemantic proximity Read ↗

Essential Role for Survivin in the Proliferative Expansion of Progenitor and Mature B Cells.Semantic proximity Read ↗

Survivin and IAP proteins in cell-death mechanismsSemantic proximity Read ↗

Essential role of survivin, an inhibitor of apoptosis protein, in T cell development, maturation, and homeostasis.Semantic proximity Read ↗

Survivin study: What is the next wave?Semantic proximity Read ↗

Survivin and Tumorigenesis: Molecular Mechanisms and Therapeutic StrategiesSemantic proximity Read ↗

Survivin: A Bifunctional Inhibitor of Apoptosis ProteinSemantic proximity Read ↗

Survivin splice variants regulate the balance between proliferation and cell death.Semantic proximity Read ↗

Oncogenes and tumour suppressors take on centrosomes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.