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Survivin Small Molecules Inhibitors: Recent Advances and Challenges

1 Feb 2023

Abstract excerpt

Survivin, as a member of the inhibitor of apoptosis proteins (IAPs) family, acts as a suppressor of apoptosis and plays a central role in cell division. Survivin has been considered as an important cancer drug target because it is highly expressed in many types of human cancers, while it is effectively absent from terminally differentiated normal tissues. Moreover, survivin is involved in tumor cell resistance to...

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PMID: 36771042
DOI: 10.3390/molecules28031376

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