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Article

The inactivation domain of STIM1 is functionally coupled with the Orai1 pore to enable Ca2+-dependent inactivation.

The Journal of general physiology - 1 Feb 2016

Mullins Franklin M, Lewis Richard S

Abstract excerpt

The inactivation domain of STIM1 (ID(STIM): amino acids 470-491) has been described as necessary for Ca(2+)-dependent inactivation (CDI) of Ca(2+) release-activated Ca(2+) (CRAC) channels, but its mechanism of action is unknown. Here we identify acidic residues within IDSTIM that control the extent of CDI and examine functional interactions of ID(STIM) with Orai1 pore residues W76 and Y80. Alanine scanning...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26809794
DOI: 10.1085/jgp.201511438
PMCID: PMC4727943

Genes

STIM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The inactivation domain of STIM1 is functionally coupled with the Orai1 pore to enable Ca2+-dependent inactivation.PMID 26809794Read ↗

A Ca2(+ )release-activated Ca2(+) (CRAC) modulatory domain (CMD) within STIM1 mediates fast Ca2(+)-dependent inactivation of ORAI1 channels.Semantic proximity Read ↗

STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels.Semantic proximity Read ↗

Differential roles of the C and N termini of Orai1 protein in interacting with stromal interaction molecule 1 (STIM1) for Ca2+ release-activated Ca2+ (CRAC) channel activation.Semantic proximity Read ↗

Physiological CRAC channel activation and pore properties require STIM1 binding to all six Orai1 subunits.Semantic proximity Read ↗

CRAC channel opening is determined by a series of Orai1 gating checkpoints in the transmembrane and cytosolic regions.Semantic proximity Read ↗

SOAR and the polybasic STIM1 domains gate and regulate Orai channels.Semantic proximity Read ↗

Molecular determinants of fast Ca2+-dependent inactivation and gating of the Orai channels.Semantic proximity Read ↗

Sequential Steps of CRAC Channel Activation.Semantic proximity Read ↗

Ca2+/Calmodulin Binding to STIM1 Hydrophobic Residues Facilitates Slow Ca2+-Dependent Inactivation of the Orai1 Channel.Semantic proximity Read ↗

Activation of STIM1-Orai1 involves an intramolecular switching mechanism.Semantic proximity Read ↗

Gated regulation of CRAC channel ion selectivity by STIM1.Semantic proximity Read ↗

The third transmembrane segment of orai1 protein modulates Ca2+ release-activated Ca2+ (CRAC) channel gating and permeation properties.Semantic proximity Read ↗

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