Article
Evolutionary rescue of a parasite population by mutation rate evolution.
Theoretical population biology - 1 Oct 2017
Greenspoon Philip B, Mideo Nicole
Abstract excerpt
The risk of antibiotic resistance evolution in parasites is a major problem for public health. Identifying factors which promote antibiotic resistance evolution is thus a priority in evolutionary medicine. The rate at which new mutations enter the parasite population is one important predictor; however, mutation rate is not necessarily a fixed quantity, as is often assumed, but can itself evolve. Here we explore...
Topics
- Alleles
- Animals
- Biological Evolution
- Computer Simulation
- Drug Resistance, Microbial
- Genetics, Population
- Host-Parasite Interactions
- Humans
- Models, Biological
- Mutation
- Mutation Rate