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Article

FRIZZLED7 Is Required for Tumor Initiation and Metastatic Growth of Melanoma Cells.

PloS one - 1 Jan 2016

Tiwary Shweta, Xu Lei

Abstract excerpt

Metastases are thought to arise from cancer stem cells and their tumor initiating abilities are required for the establishment of metastases. Nevertheless, in metastatic melanoma, the nature of cancer stem cells is under debate and their contribution to metastasis formation remains unknown. Using an experimental metastasis model, we discovered that high levels of the WNT receptor, FZD7, correlated with enhanced...

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Share to Cell Line, Tumor
Share to Cell Proliferation
Share to Frizzled Receptors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knockdown Techniques

Share to Melanoma

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Share to Proto-Oncogene Proteins B-raf

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Source

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Identifiers

PMID: 26808375
DOI: 10.1371/journal.pone.0147638
PMCID: PMC4726610

Genes

FZD7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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