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Article

FZD8, a target of p53, promotes bone metastasis in prostate cancer by activating canonical Wnt/β-catenin signaling.

Cancer letters - 28 Aug 2017

Li Qiji, Ye Liping, Zhang Xin, Wang Min, Lin Chuyong, Huang Shuai, Guo Wei, Lai Yingrong, Du Hong, Li Jun, Song Libing, Peng Xinsheng

Abstract excerpt

Prostate cancer (PCa) is the second most frequently diagnosed cancer among men and exhibits a high propensity to metastasize to bone. Currently, bone metastasis remains incurable, and therapies are limited. A better understanding of the molecular mechanisms involved in PCa bone metastasis is needed to develop more effective therapeutics for this disease. Herein, we reported that among the FZD family, FZD8 was...

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PMID: 28602974
DOI: 10.1016/j.canlet.2017.05.029

Genes

FZD8

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