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Interference of FZD2 suppresses proliferation, vasculogenic mimicry and stemness in glioma cells via blocking the Notch/NF‑κB signaling pathway

23 Jul 2024

Abstract excerpt

Frizzled family protein 2 (FZD2) is widely associated with tumor development and metastasis. The present study aimed to gain an insight into the role and regulatory mechanism of FZD2 in glioma. The expression level of FZD2 in normal astrocyte and glioma cells was determined by reverse transcription‑quantitative PCR and western blotting, and cell transfection was conducted for FZD2 expression knockdown. Malignant...

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PMID: 39091630
DOI: 10.3892/etm.2024.12662

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