Article
WNT5A enhances resistance of melanoma cells to targeted BRAF inhibitors.
The Journal of clinical investigation - 1 Jul 2014
Anastas Jamie N, Kulikauskas Rima M, Tamir Tigist, Rizos Helen, Long Georgina V, von Euw Erika M, Yang Pei-Tzu, Chen Hsiao-Wang, Haydu Lauren, Toroni Rachel A, Lucero Olivia M, Chien Andy J, Moon Randall T
Abstract excerpt
About half of all melanomas harbor a mutation that results in a constitutively active BRAF kinase mutant (BRAF(V600E/K)) that can be selectively inhibited by targeted BRAF inhibitors (BRAFis). While patients treated with BRAFis initially exhibit measurable clinical improvement, the majority of pa...
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