Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ZBTB7A Suppresses Melanoma Metastasis by Transcriptionally Repressing MCAM.

Molecular cancer research : MCR - 1 Aug 2015

Liu Xue-Song, Genet Matthew D, Haines Jenna E, Mehanna Elie K, Wu Shaowei, Chen Hung-I Harry, Chen Yidong, Qureshi Abrar A, Han Jiali, Chen Xiang, Fisher David E, Pandolfi Pier Paolo, Yuan Zhi-Min

Abstract excerpt

UNLABELLED: The excessive metastatic propensity of melanoma makes it the most deadly form of skin cancer, yet the underlying mechanism of metastasis remains elusive. Here, mining of cancer genome datasets discovered a frequent loss of chromosome 19p13.3 and associated downregulation of the zinc finger transcription factor ZBTB7A in metastatic melanoma. Functional assessment of ZBTB7A-regulated genes identified...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Lentivirus
Share to Melanoma

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Nude

Share to Neoplasm Invasiveness

Share to Neoplasm Metastasis

Share to Neoplasm Transplantation

Share to Skin Neoplasms

Share to Zinc Fingers

Source

Open in PubMed Open full text

Identifiers

PMID: 25995384
DOI: 10.1158/1541-7786.MCR-15-0169
PMCID: PMC4543565

Genes

MCAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ZBTB7A Suppresses Melanoma Metastasis by Transcriptionally Repressing MCAM.PMID 25995384Read ↗

MCAM expression facilitates melanoma-endothelial interactions and promotes metastatic disease progressionSemantic proximity Read ↗

The prognostic and immunological effects of ZBTB7C across cancers: friend or foe?Semantic proximity Read ↗

Mutated MITF-E87R in Melanoma Enhances Tumor Progression via S100A4.Semantic proximity Read ↗

The role of N-Cadherin, MCAM, and β3 integrin in melanoma progression, proliferation, migration and invasionSemantic proximity Read ↗

Cell Adhesion Molecules in Normal Skin and MelanomaSemantic proximity Read ↗

Multi-omics Profiling Shows BAP1 Loss Is Associated with Upregulated Cell Adhesion Molecules in Uveal MelanomaSemantic proximity Read ↗

Melanoma inhibitory activity (MIA): an important molecule in melanoma development and progressionSemantic proximity Read ↗

Glypican 6 is a putative biomarker for metastatic progression of cutaneous melanomaSemantic proximity Read ↗

B7-H3 is associated with the armored-cold phenotype and predicts poor immune checkpoint blockade response in melanoma.Semantic proximity Read ↗

CEACAM1 promotes melanoma cell growth through Sox-2.Semantic proximity Read ↗

FBXW7 mutations in melanoma and a new therapeutic paradigm.Semantic proximity Read ↗

Somatic mutational landscapes of adherens junctions and their functional consequences in cutaneous melanoma development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.