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Article

Adenomatous polyposis coli (APC) regulates miR17-92 cluster through β-catenin pathway in colorectal cancer.

Oncogene - 1 Sept 2016

Li Yajuan, Lauriola Mattia, Kim Donghwa, Francesconi Mirko, D'Uva Gabriele, Shibata Dave, Malafa Mokenge P, Yeatman Timothy J, Coppola Domenico, Solmi Rossella, Cheng Jin Q

Abstract excerpt

Adenomatous polyposis coli (APC) mutation is the most common genetic change in sporadic colorectal cancer (CRC). Although deregulations of miRNAs have been frequently reported in this malignancy, APC-regulated miRNAs have not been extensively documented. Here, by using an APC-inducible cell line and array analysis, we identified a total of 26 deregulated miRNAs. Among them, members of miR-17-92 cluster were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26804172
DOI: 10.1038/onc.2015.522
PMCID: PMC4960006

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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