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Article

MicroRNA-494 promotes cancer progression and targets adenomatous polyposis coli in colorectal cancer.

Molecular cancer - 5 Jan 2018

Zhang Ying, Guo Lu, Li Yuhuan, Feng Gui-Hai, Teng Fei, Li Wei, Zhou Qi

Abstract excerpt

BACKGROUND: Aberrant activation of the Wnt/β-catenin signaling pathway is frequently observed in colorectal cancer (CRC). β-catenin is the major Wnt signaling pathway effector and inactivation of adenomatous polyposis coli (APC) results in nuclear accumulation of β-catenin. It has been suggested that inactivation of APC plays an important role in activation of the Wnt/β-catenin pathway and in the progression of...

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Share to Adenomatous Polyposis Coli
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29304823
DOI: 10.1186/s12943-017-0753-1
PMCID: PMC5755155

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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