Sphingosine 1-phospate differentially modulates maturation and function of human Langerhans-like cells.

doi:10.1016/j.jdermsci.2016.01.002

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Article

Sphingosine 1-phospate differentially modulates maturation and function of human Langerhans-like cells.

Journal of dermatological science - 1 Apr 2016

Bock Stephanie, Pfalzgraff Anja, Weindl Günther

Abstract excerpt

BACKGROUND: As mediators between innate and adaptive immune responses, Langerhans cells (LCs) are in the focus of recent investigations to determine their role in allergic inflammatory diseases like allergic contact dermatitis and atopic dermatitis. Sphingosine 1-phosphate (S1P) is a crucial lipid mediator in the skin and potentially interferes with LC homeostasis but also functional properties, such as cytokine...

Topics

Cell Differentiation
Cell Line, Tumor
Cell Movement
Cytokines
Endocytosis
Fingolimod Hydrochloride
Humans
Langerhans Cells
Lysophospholipids
Phenotype
Receptors, Lysosphingolipid
Signal Transduction
Sphingosine

Source

Open in PubMed

Identifiers

PMID: 26803226
DOI: 10.1016/j.jdermsci.2016.01.002

Genes

CCL20
CCL21

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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