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Article

Impact of allogeneic hematopoietic cell transplant in patients with myeloid neoplasms carrying spliceosomal mutations.

American journal of hematology - 1 Jun 2016

Hamilton Betty Ky, Visconte Valeria, Jia Xuefei, Tabarroki Ali, Makishima Hideki, Hasrouni Edy, Abounader Donna, Kalaycio Matt, Sekeres Mikkael A, Sobecks Ronald, Duong Liu Hien, Bolwell Brian, Maciejewski Jaroslaw P, Copelan Edward, Tiu Ramon V

Abstract excerpt

Molecular predictors of outcome are increasingly important in determining optimal therapy for myeloid neoplasms. Mutations in the spliceosomal genes (U2AF1 and SRSF2) predict for poor outcomes in myelodysplastic syndromes (MDS) and related diseases. We investigated the effect of hematopoietic cell transplant (HCT) on the negative prognostic impact of U2AF1 and SRSF2 mutations. In total, 122 patients with MDS...

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Share to Leukemia, Myeloid
Share to Myelodysplastic Syndromes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ribonucleoproteins

Share to Serine-Arginine Splicing Factors

Share to Spliceosomes

Share to Splicing Factor U2AF

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Share to Transplantation, Homologous

Source

Identifiers

PMID: 26799334
DOI: 10.1002/ajh.24306

Genes

SRSF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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