Impact of spliceosome mutation on outcomes of myelodysplastic syndrome and chronic myelomonocytic leukemia patients undergoing allogeneic hematopoietic cell transplantation.

doi:10.1016/j.leukres.2024.107565

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Impact of spliceosome mutation on outcomes of myelodysplastic syndrome and chronic myelomonocytic leukemia patients undergoing allogeneic hematopoietic cell transplantation.

Leukemia research - 1 Oct 2024

Desai Amrita, Samara Yazeed, Yang Dongyun, Ball Brian, Braun Adam, Koller Paul, Blackmon Amanda, Agrawal Vaibhav, Pourhassan Hoda, Amanam Idoroenyi, Arslan Shukaib, Otoukesh Salman, Sandhu Karamjeet, Aldoss Ibrahim, Ali Haris, Salhotra Amandeep, Al Malki Monzr M, Artz Andrew, Becker Pamela, Smith Eileen, Stein Anthony, Marcucci Guido, Forman Stephen J, Curtin Peter, Nakamura Ryotaro, Pullarkat Vinod

Abstract excerpt

INTRODUCTION: Allogeneic Hematopoietic cell transplantation (allo-HCT) remains the only curative therapy for myelodysplastic syndrome (MDS) and chronic myelomonocytic leukemia (CMML). The impact of spliceosome mutations on allo-HCT outcome is unclear and further understanding is needed to assess the implications of this class of mutations on risk of relapse, overall survival (OS) and non-relapse mortality (NRM)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Graft vs Host Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hematopoietic Stem Cell Transplantation

Share to Leukemia, Myelomonocytic, Chronic

Share to Myelodysplastic Syndromes

Share to Spliceosomes

Share to Survival Rate

Share to Transplantation Conditioning

Share to Transplantation, Homologous

Source

Open in PubMed

Identifiers

PMID: 39208597
DOI: 10.1016/j.leukres.2024.107565

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of spliceosome mutation on outcomes of myelodysplastic syndrome and chronic myelomonocytic leukemia patients undergoing allogeneic hematopoietic cell transplantation.PMID 39208597Read ↗

Allogeneic Hematopoietic Cell Transplantation in Patients With Acute Myeloid Leukemia With Myelodysplasia-Related Genetic Features: Relevance of the Genetic Underlying Category. A Retrospective Analysis on Behalf of the Acute Leukemia Working Party of the EBMT.Semantic proximity Read ↗

Allogeneic Stem Cell Transplant for Myelofibrosis and Myelodysplastic Syndromes: A Contemporary Review.Semantic proximity Read ↗

Targeting Splicing in the Treatment of Myelodysplastic Syndromes and Other Myeloid Neoplasms.Semantic proximity Read ↗

Impact of allogeneic hematopoietic cell transplant in patients with myeloid neoplasms carrying spliceosomal mutations.Semantic proximity Read ↗

Integrating Genomics in Myelodysplastic Syndrome to Predict Outcomes After Allogeneic Hematopoietic Cell Transplantation.Semantic proximity Read ↗

Superior outcome of upfront allogeneic hematopoietic cell transplantation versus hypomethylating agent induction in myelodysplastic syndromeSemantic proximity Read ↗

Clinical Effects of Driver Somatic Mutations on the Outcomes of Patients With Myelodysplastic Syndromes Treated With Allogeneic Hematopoietic Stem-Cell TransplantationSemantic proximity Read ↗

Targeted Next-Generation Sequencing in Myelodysplastic Syndrome and Chronic Myelomonocytic Leukemia Aids Diagnosis in Challenging Cases and Identifies Frequent Spliceosome Mutations in Transformed Acute Myeloid Leukemia.Semantic proximity Read ↗

Clinical utility and real-world application of molecular genetic sequencing in the management of patients with acute myeloid leukemia and myelodysplastic syndromes.Semantic proximity Read ↗

Perspective on how to approach molecular diagnostics in acute myeloid leukemia and myelodysplastic syndromes in the era of next-generation sequencing.Semantic proximity Read ↗

Mutation Clearance after Transplantation for Myelodysplastic Syndrome.Semantic proximity Read ↗

Allogeneic Hematopoietic Cell Transplantation Improves Outcome in Myelodysplastic Syndrome Across High-Risk Genetic Subgroups: Genetic Analysis of the Blood and Marrow Transplant Clinical Trials Network 1102 Study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.