Article

Loss of endothelial glucocorticoid receptor accelerates organ fibrosis in <i>db/db</i> mice

2023-03-23

Abstract excerpt

Endothelial cells play a key role in maintaining homeostasis and are deranged in many disease processes, including fibrotic conditions. Absence of the endothelial glucocorticoid receptor (GR) has been shown to accelerate diabetic kidney fibrosis in part through up regulation of Wnt signaling. The db/db mouse model is a model of spontaneous type 2 diabetes that has been noted to develop fibrosis in multiple organs...

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Identifiers and source

Literature Corpus work: 5595bd56-63c7-5130-a89d-4018caa84baf
DOI: 10.1101/2023.03.20.533532

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