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Article

Decoy receptor 2 mediates the apoptosis-resistant phenotype of senescent renal tubular cells and accelerates renal fibrosis in diabetic nephropathy.

Cell death & disease - 3 Jun 2022

Chen Jia, Chen Ke-Hong, Wang Li-Ming, Luo Jia, Zheng Quan-You, He Ya-Ni

Abstract excerpt

Apoptotic resistance leads to persistent accumulation of senescent cells and sustained expression of a senescence-associated secretory phenotype, playing an essential role in the progression of tissue fibrosis. However, whether senescent renal tubular epithelial cells (RTECs) exhibit an apoptosis-resistant phenotype, and the role of this phenotype in diabetic nephropathy (DN) remain unclear. Our previous study...

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Identifiers

PMID: 35661704
DOI: 10.1038/s41419-022-04972-w
PMCID: PMC9166763

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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