Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The proinflammatory phenotype of PECAM-1-deficient mice results in atherogenic diet-induced steatohepatitis.

American journal of physiology. Gastrointestinal and liver physiology - 1 Dec 2007

Goel Reema, Boylan Brian, Gruman Lynn, Newman Peter J, North Paula E, Newman Debra K

Abstract excerpt

The severity of nonalcoholic steatohepatitis (NASH) is determined by environmental and genetic factors, the latter of which are incompletely characterized. Platelet endothelial cell adhesion molecule-1 (PECAM-1) is a 130-kDa transmembrane glycoprotein expressed on blood and vascular cells. In the present study, we provide data for the novel finding that genetic deficiency of PECAM-1 potentiates the development...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Atherosclerosis
Share to Diet, Atherogenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis

Share to Immunologic Factors

Share to Mice, Inbred C57BL

Share to Mice, Knockout

Share to Platelet Endothelial Cell Adhesion Molecule-1

Source

Identifiers

PMID: 17932230
DOI: 10.1152/ajpgi.00157.2007

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The proinflammatory phenotype of PECAM-1-deficient mice results in atherogenic diet-induced steatohepatitis.PMID 17932230Read ↗

Pioglitazone attenuates hepatic inflammation and fibrosis in phosphatidylethanolamine N-methyltransferase-deficient mice.Semantic proximity Read ↗

Hepatic MCPIP1 protein levels are reduced in NAFLD patients and are predominantly expressed in cholangiocytes and liver endotheliumSemantic proximity Read ↗

Complement 3a Receptor 1 on Macrophages and Kupffer cells is not required for the Pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver DiseaseSemantic proximity Read ↗

Role of Mcpip1 in obesity-induced hepatic steatosis as determined by myeloid and liver-specific conditional knockoutsSemantic proximity Read ↗

Hepatocyte-independent PAR1-biased signaling controls liver pathology in experimental obesity.Semantic proximity Read ↗

Pin1 Plays Essential Roles in NASH Development by Modulating Multiple Target Proteins.Semantic proximity Read ↗

Melanocortin 4 receptor-deficient mice as a novel mouse model of nonalcoholic steatohepatitis.Semantic proximity Read ↗

Exosomal novel-miRNA-126 mediates vascular endothelial dysfunction by targeting AhR-NLRP3 pathway in nonalcoholic steatohepatitisSemantic proximity Read ↗

Intercellular adhesion molecule-1 protects against adipose tissue inflammation and insulin resistance but promotes liver inflammation and hepatic fibrosis in miceSemantic proximity Read ↗

Methionine- and Choline-Deficient Diet-Induced Nonalcoholic Steatohepatitis Is Associated with Increased Intestinal Inflammation.Semantic proximity Read ↗

Kupffer Cells Undergo Fundamental Changes during the Development of Experimental NASH and Are Critical in Initiating Liver Damage and InflammationSemantic proximity Read ↗

Myeloid- and hepatocyte-specific deletion of group VIA calcium-independent phospholipase A2 leads to dichotomous opposing phenotypes during MCD diet-induced NASH.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.