Immunohistochemistry is highly sensitive and specific for detecting the BRAF V600E mutation in papillary thyroid carcinoma.

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Article

Immunohistochemistry is highly sensitive and specific for detecting the BRAF V600E mutation in papillary thyroid carcinoma.

International journal of clinical and experimental pathology - 1 Jan 2015

Sun Jian, Zhang Jing, Lu Junliang, Gao Jie, Lu Tao, Ren Xinyu, Duan Huanli, Liang Zhiyong

Abstract excerpt

The V600E mutation in the B-type Raf kinase (BRAF) gene is a common genetic change in cases of papillary thyroid carcinoma (PTC) that appears to play a key role in the development and progression of this disease. We sought to assess the sensitivity and specificity of immunohistochemical detection of this mutation with a V600E mutated BRAF antibody in a Chinese PTC cohort. In this study, we used fully automated...

Topics

Adolescent
Adult
Aged
Biomarkers, Tumor
Carcinoma
Carcinoma, Papillary
Child
DNA Mutational Analysis
Female
Humans
Immunohistochemistry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Mutation

Proto-Oncogene Proteins B-raf

Real-Time Polymerase Chain Reaction

Thyroid Cancer, Papillary

Thyroid Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 26823846
PMCID: PMC4713632

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-26823846-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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