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Article

Immunohistochemistry is highly sensitive and specific for detecting the BRAF V600E mutation in papillary thyroid carcinoma.

International journal of clinical and experimental pathology - 1 Jan 2015

Sun Jian, Zhang Jing, Lu Junliang, Gao Jie, Lu Tao, Ren Xinyu, Duan Huanli, Liang Zhiyong

Abstract excerpt

The V600E mutation in the B-type Raf kinase (BRAF) gene is a common genetic change in cases of papillary thyroid carcinoma (PTC) that appears to play a key role in the development and progression of this disease. We sought to assess the sensitivity and specificity of immunohistochemical detection of this mutation with a V600E mutated BRAF antibody in a Chinese PTC cohort. In this study, we used fully automated...

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Identifiers

PMID: 26823846
PMCID: PMC4713632

Genes

BRAF

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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