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Article

Evaluation of the characteristics of leucyl-tRNA synthetase (LeuRS) inhibitor AN3365 in combination with different antibiotic classes.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology - 1 Nov 2016

Monteferrante C G, Jirgensons A, Varik V, Hauryliuk V, Goessens W H F, Hays J P

Abstract excerpt

Aminoacyl tRNA synthetases are enzymes involved in the key process of coupling an amino acid to its cognate tRNA. AN3365 is a novel antibiotic that specifically targets leucyl-tRNA synthetase, whose development was halted after evaluation in phase II clinical trials owing to the rapid selection of resistance. In an attempt to bring AN3365 back into the developmental pipeline we have evaluated the efficacy of...

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Identifiers

PMID: 27506217
DOI: 10.1007/s10096-016-2738-1
PMCID: PMC5059401

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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