Article
[The mechanisms of prostate cancer progression through androgen receptor].
Nihon rinsho. Japanese journal of clinical medicine - 1 Jan 2016
Goto Yusuke, Sakamoto Shinichi, Ichikawa Tomohiko
Abstract excerpt
Androgen receptor(AR) has a critical role in prostate cancer(PCa) progression and targeting AR axis signaling by androgen deprivation therapy is a standard treatment for advanced PCa. Recently, the role of AR even in castration-resistant PCa(CRPC) is well recognized and emerging evidence suggests survival advantages of treatment by targeting AR in CRPC. This review outlines AR functions that contribute to PCa...
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