Article
Genetic alterations in uterine fibroids - a new direction for pharmacological intervention?
Expert opinion on therapeutic targets - 1 Jan 2015
Markowski Dominique N, Holzmann Carsten, Bullerdiek Jörn
Abstract excerpt
INTRODUCTION: Though uterine leiomyomas (UL) (syn.: fibroids) are by far the most frequent human symptomatic tumors their pathogenesis still remains to be elucidated. From the detection of microscopically visible alterations of chromosomal structure and molecular cytogenetic analyses, as well as from transcriptome and genome analyses, a picture of a heterogeneous group of benign clonal smooth muscle neoplasms...
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